uck2 inhibitor Search Results


uck2 inhibitor  (MedChemExpress)
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MedChemExpress uck2 inhibitor
( A ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with various doses of the IMPDH inhibitor for 96 h. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( B ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells cultured with the indicated concentrations of glucose. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis. ( C–E ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the <t>UCK2</t> inhibitor for 96 h at 10 mM ( C ), 5 mM ( D ) and 2.5 mM ( E ) glucose. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( F–H ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the DHODH inhibitor for 96 h at 10 mM ( F ), 5 mM ( G ) and 2.5 mM ( H ) glucose. Representative data from three independent experiments were shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( I ) The differences in LFQ intensities from 480 label-free proteomes of the indicated markers between the H2452 sg NF2 -1 and sgCtrl groups. The data are presented as the mean ± SD ( n = 3). A two-tailed unpaired t test was used for statistical analysis. ( J , K ) The mRNA expression of UPP1 ( J ) and cell viability ( K ) of the indicated cell populations transfected with small interfering RNA (siRNA) targeting the negative control or UPP1 for 72 h. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis.
Uck2 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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uck2 inhibitor - by Bioz Stars, 2026-10
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uck2 inhibitor-1  (MuseChem Chemicals)
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UCK2 Inhibitor-1 (Cat No.: I042618) is a selective small-molecule inhibitor targeting uridine-cytidine kinase 2 (UCK2), an enzyme involved in the pyrimidine salvage pathway essential for nucleotide biosynthesis. Overexpressed in certain cancers, UCK2 contributes to tumor
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uck2 inhibitor-3  (TargetMol)
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uck2 inhibitor-2  (TargetMol)
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( A ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with various doses of the IMPDH inhibitor for 96 h. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( B ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells cultured with the indicated concentrations of glucose. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis. ( C–E ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the UCK2 inhibitor for 96 h at 10 mM ( C ), 5 mM ( D ) and 2.5 mM ( E ) glucose. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( F–H ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the DHODH inhibitor for 96 h at 10 mM ( F ), 5 mM ( G ) and 2.5 mM ( H ) glucose. Representative data from three independent experiments were shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( I ) The differences in LFQ intensities from 480 label-free proteomes of the indicated markers between the H2452 sg NF2 -1 and sgCtrl groups. The data are presented as the mean ± SD ( n = 3). A two-tailed unpaired t test was used for statistical analysis. ( J , K ) The mRNA expression of UPP1 ( J ) and cell viability ( K ) of the indicated cell populations transfected with small interfering RNA (siRNA) targeting the negative control or UPP1 for 72 h. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis.

Journal: EMBO Molecular Medicine

Article Title: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2 -deficient mesothelioma

doi: 10.1038/s44321-025-00278-4

Figure Lengend Snippet: ( A ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with various doses of the IMPDH inhibitor for 96 h. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( B ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells cultured with the indicated concentrations of glucose. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis. ( C–E ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the UCK2 inhibitor for 96 h at 10 mM ( C ), 5 mM ( D ) and 2.5 mM ( E ) glucose. Representative data from three independent experiments are shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( F–H ) Cell viability of H2452 NF2 wild-type (sgCtrl) and NF2 knockout (sg NF2 -1, sg NF2 -2) cells treated with the indicated doses of the DHODH inhibitor for 96 h at 10 mM ( F ), 5 mM ( G ) and 2.5 mM ( H ) glucose. Representative data from three independent experiments were shown. The data are presented as the mean ± SD. Two-way ANOVA with multiple comparisons was used for statistical analysis. ( I ) The differences in LFQ intensities from 480 label-free proteomes of the indicated markers between the H2452 sg NF2 -1 and sgCtrl groups. The data are presented as the mean ± SD ( n = 3). A two-tailed unpaired t test was used for statistical analysis. ( J , K ) The mRNA expression of UPP1 ( J ) and cell viability ( K ) of the indicated cell populations transfected with small interfering RNA (siRNA) targeting the negative control or UPP1 for 72 h. The data are presented as the mean ± SD ( n = 3). Two-way ANOVA with multiple comparisons was used for statistical analysis.

Article Snippet: UCK2 inhibitor , MedChemExpress , HY-148394.

Techniques: Knock-Out, Cell Culture, Two Tailed Test, Expressing, Transfection, Small Interfering RNA, Negative Control